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AUA AWARD WINNERS The AUA/Urology Care Foundation™ Research Scholar Award: Accelerating Breakthroughs in Neurourology Research

By: Betsy H. Salazar, PhD, Houston Methodist Hospital, Weill Cornell Medical College, Texas; Argyrios Stampas, MD, MS, University of Texas Health Science Center at Houston TIRR Memorial Hermann, Houston, Texas; Rose Khavari, MD, Houston Methodist Hospital, Weill Cornell Medical College, Texas | Posted on: 19 Apr 2024

The AUA truly embodies medical excellence and dedication to patient-centered care. It actively facilitates advancements in the field of urology by prioritizing the education of physicians, supporting research, and advocating for patients through prudent health care policy. Not only am I honored to be a member of this prestigious organization but also truly humbled by the receipt of this important award.

I firmly believe the training and research opportunities I have experienced thus far and the exceptional mentors I have had have paved the way for not only my development as a scientist, but also laid the foundation for the success epitomized by this award. My path into a research career in the field of urology started shortly after graduating with my doctoral degree in biomedical engineering from the University of Houston, when I took a postdoctoral fellow position at the Houston Methodist Research Institute under the direction of Drs Timothy Boone and Alvaro Muñoz. Here I focused on applying the knowledge I acquired in electrode design and electrophysiological assessments during my doctoral training to study the electrical activity of the lower urinary tract (LUT) in intact and spinal cord injury rodent models and understand the underlying mechanisms that govern its function. During my tenure in the Boone-Muñoz lab, I gained invaluable experience in the field of neurourology and uncovered my passion for this field of research. Subsequently, I transitioned to the Center for Neuroregeneration at the Houston Methodist Research Institute, where I was under the mentorship of Dr Philip Horner. In the Horner lab I was able to leverage my comprehensive scientific training in electrophysiology to implement neuromodulatory techniques and deepen our understanding of neural plasticity and exploring the potential for neuroregeneration.

Transitioning to the urology department at Houston Methodist, a pivotal move facilitated by Dr Rose Khavari, has allowed me to expand my research into the realm of human investigation. In this new and exciting stage of my career, I aim to unravel the intricacies of spinal and supraspinal networks governing bladder control (Figure). Additionally, I also strive to identify neuro-targets to drive the development of individualized treatments leveraging neuroplasticity to augment LUT function and improve the quality of life of individuals with neurogenic LUT dysfunction.

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Figure. Preliminary data from our pilot study focused on developing a protocol capable of detecting changes in spinal activation elicited by simulated bulbocavernosus reflex during empty (blue) and full (red) bladder states. This project was funded by a CAIRIBU Collaboration Award.

The support from this award provides me the opportunity to pursue these objectives. Specifically, this study focuses on utilizing functional imaging to characterize neural activity of supraspinal (Aim 1) and spinal (Aim 2) areas involved in the delicate and complex coordination of LUT function (bladder storage and voiding) in individuals with spinal cord injury (SCI). Under the guidance of Dr Rose Khavari (primary mentor), a leader in the field of neurourology research, and Dr Argyrios Stampas (co-mentor), an expert in clinical SCI neuromodulation and rehabilitation, I believe we have the necessary tools to make a meaningful contribution to the field of neurourology research.

While this study will begin looking specifically at alterations in activity of neural networks associated with bladder function in the SCI population, this is merely the first step in deepening our understanding of the brain-bladder connection. The inception of any scientific process lies in comprehending the intricacies of the problem. In this context, delving into the nuances of central nervous system activation during bladder filling and emptying after neurodegeneration represents the foundation upon which future advancements can be built.

The significance of this research extends beyond the confines of my immediate focus. This award not only acknowledges the merit of my current investigation, but also serves as a catalyst for further scientific pursuits. In the coming years, I aim to broaden my scope, taking on new projects and delving into emerging topics within urology and neurourology. This award provides the impetus and resources necessary to push the boundaries of knowledge. Through sustained efforts and continued engagement with the AUA community, I anticipate making enduring contributions that will shape the landscape of urological research and ultimately benefit patients with various neurological disorders.

I am exceptionally grateful to all the mentors that have supported me in my research endeavors. They have fueled the fire in me for knowledge, fostered a mind for constant learning and innovation, and been instrumental in guiding me on my career up to this point, playing a major role in my reception of this award. I am particularly grateful to Dr Khavari for her mentorship and unwavering support, which has laid a strong foundation for a career in clinical research with the potential for having a meaningful impact in the field of neurourology.

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